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Frailty is one postulated result of inadequate vitamin D status in older populations. In this observational study, researchers assessed cross-sectional and longitudinal relations between vitamin D levels and a five-item measure of frailty.
In a cohort of about 6300 older white women (mean age, 77), the relation between baseline serum 25-hydroxyvitamin D (25[OH]D) level and frailty was “U-shaped”: Compared with women who had serum 25(OH)D levels between 20 and 30 ng/mL, women with levels <15 ng/mL were significantly more likely to be frail (odds ratio, 1.47), but the same was true for women with levels ≥30 ng/mL (OR, 1.32). The U-shaped relation also existed in the subgroup of women who took no vitamin D supplements. During 5 years of follow-…