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Cardiopulmonary resuscitation (CPR) is more efficient with use of two devices: a chest-wall suction device that allows active decompression as well as compression of the chest, and an airway impedance-threshold device that limits passive ventilation during chest decompression. In animal and some human studies, these devices increase negative intrathoracic pressure between compressions, thereby improving venous return and perfusion of myocardium and brain with each compression. But clinical tests of these devices have been limited.
Investigators randomized 1653 adults with out-of-hospital cardiac arrests in seven U.S. regions to receive either active compression-decompression (ACD) CPR with airway impedance-threshold devices or traditional CP…