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Some patients with symptoms of irritable bowel syndrome (IBS), but no evidence of celiac disease, report gluten sensitivity. To determine whether these observations hold up under double-blind, placebo-controlled conditions, Australian researchers enrolled 34 adults in whom celiac disease had been ruled out by standard criteria but who reported intolerance to gluten-containing products. They all followed their typical gluten-free diets and, additionally, were randomized to receive either gluten-containing or gluten-free (placebo) bread and muffins daily for 6 weeks.
The proportion of patients who reported inadequate control of overall symptoms was significantly higher in the gluten group than in the placebo group (68% vs. 40%). Several specif…