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Recent evidence suggests that statins lower risk for atrial fibrillation (AF). To further investigate this association, researchers conducted a meta-analysis of randomized, controlled trials in which statin treatment was compared with no statin treatment or in which high-dose statins were compared with standard-dose statins.
Analysis of data from 13 short-term trials (average follow-up range, 1 week to 5 months; 4400 patients) showed that statins, compared with placebo, significantly lowered risk for AF (odds ratio, 0.6). In contrast, analysis of data from 22 long-term trials (average follow-up range, 1.0 to 5.3 years; 106,000 patients) showed that compared with placebo, statins did not lower risk for AF (OR, 0.95). Likewise, seven long-term…