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Multiple studies have shown that albuminuria and low estimated glomerular filtration rate (eGFR) predict development of adverse cardiovascular outcomes. Using data from two large studies — ONTARGET (JW Gen Med Sep 2 2008) and TRANSCEND (JW Cardiol Sep 17 2008) — involving more than 27,000 patients (age, >55) who had vascular disease or diabetes with symptoms of end-organ involvement, researchers evaluated whether eGFR and albuminuria added predictive power beyond that of traditional risk factors.
Mean follow-up was 4.6 years. Low eGFR and elevated urine albumin–creatinine ratios were associated with excess risk for cardiovascular-related death, myocardial infarction, stroke, or hospitalization for heart failure. However, after controlling fo…