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Proton-pump inhibitors (PPIs) are prescribed widely to prevent peptic ulcers in patients taking aspirin. PPIs, however, can lower aspirin absorption, which, in turn, could attenuate aspirin's antiplatelet effect. In this retrospective study, Danish investigators assessed the effect of PPI therapy on adverse cardiovascular (CV) events in nearly 20,000 aspirin-treated patients who survived 30 days after a first myocardial infarction (MI). Notably, clopidogrel-treated patients were excluded.
During 1-year follow-up, 3400 patients (17%) experienced recurrent MI, stroke, or CV-related death. In a propensity-score matched model (which is designed to compensate for confounding factors and baseline differences), risk for the combined endpoint of CV-…