Subsequent Cancers in Survivors of Childhood Cancer

Excess risk was especially high for survivors of retinoblastoma, Hodgkin lymphoma, and Wilms tumor.

Survivors of childhood cancer are at excess risk for developing cancer as adults. In a population-based prospective cohort study, researchers used a British registry of childhood cancer survivors to conduct a detailed assessment of this risk. The nearly 18,000 registrants had survived for at least 5 years after receiving cancer diagnoses before age 15 years. Risk was assessed by standardized incidence ratios (SIRs) that compared actual rates to expected rates in the British general population.

During median follow-up of 24 years, 1354 subsequent cancers were diagnosed. Excluding nonglioma central nervous system cancer and nonmelanoma skin cancer (for which population-based risk estimates are inaccurate), the overall SIR for any subsequent ca…

Reviewing Author

Thomas L. Schwenk, MD

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Thomas L. Schwenk, MD

Disclosures

Editorial BoardsUpToDate