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In 2001, a randomized trial supported intensive glycemic control for mostly nondiabetic patients in a surgical intensive care unit (ICU; JW Gen Med Nov 16 2001). In more recent studies, however, investigators have failed to duplicate those findings in medical or mixed medical-surgical ICU populations.
In this randomized trial, Boston University researchers concentrated specifically on perioperative glycemic control in diabetic patients undergoing coronary artery bypass grafting (CABG). Eighty-two such patients received either aggressive (target glucose level, 90–120 mg/dL) or moderate (target glucose, 120–180 mg/dL) glycemic control, starting at induction of anesthesia. The intervention continued postoperatively in an ICU for 18 hours, at wh…