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In this population-based, nationwide cohort study of Finnish patients with type 1 diabetes, investigators examined time trends for mortality among 10,500 patients who developed early-onset disease (age range, 0–14 years) and 6800 who developed late-onset disease (age range, 15–29) between 1970 and 1999. Mean follow-up was 21.4 years.
Excess mortality was higher in the early-onset group than in the late-onset group (standardized mortality ratio [SMR], 3.6 for early-onset and 2.8 for late-onset vs. the general population). At 20 years' duration of diabetes, SMRs for the early-onset group were lower in patients whose diagnoses were made in 1985–1989 than in patients with diagnoses in 1970–1974, whereas SMRs in the late-onset group were higher i…