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On October 11, 2011, the U.S. Preventive Services Task Force (USPSTF) posted a draft recommendation statement on screening for prostate cancer. In its 2008 guideline on this topic, the USPSTF concluded that evidence was insufficient to make a recommendation in men younger than 75, but it recommended against screening older men (age, ≥75). Now, 3 years later, the USPSTF recommends against prostate-specific antigen (PSA)-based screening for prostate cancer in all age groups.
The impetus for the USPSTF's revisiting of PSA screening is the recent publication of mortality results from two large randomized screening trials (JW Gen Med Mar 18 2009). A U.S. trial showed no benefit from screening but was tainted by substantial screening outside the t…