Loading...
Using portable testing devices, patients who take warfarin now can monitor their international normalized ratios (INRs) at home and either can report them to their clinicians for dose adjustment (self-testing) or use an algorithm to adjust their own doses (self-management). In this meta-analysis, U.K. researchers combined individual patient data from 11 randomized trials in which self-monitoring was compared with conventional care in 6417 adult patients. Maximum follow-up was 5 years.
Compared with patients who received conventional care, those assigned to self-monitoring had significantly fewer thromboembolic events (hazard ratio, 0.51) and had nonsignificant trends toward fewer hemorrhagic events (HR, 0.88) and deaths (HR, 0.82). Risk for …