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In laboratory and simulator settings, cannabis consumption impairs driving skills, but whether the same is true for real-world driving is unclear. In this meta-analysis of nine observational studies involving more than 49,000 participants, investigators examined whether acute cannabis consumption (determined by toxicologic analysis of whole blood or by self-report) raises risk for motor vehicle accidents (MVAs).
Driving under the influence of cannabis was associated with significantly higher risk for MVAs (odds ratio, 1.9) than was unimpaired driving. Similar results were obtained for analyses involving only case-control studies (OR, 2.8); culpability studies, which consider driver responsibility for MVAs (OR, 1.7); and studies of fatal MVAs…