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Patients who suffer from protracted Clostridium difficile colitis despite receiving oral antibiotic therapy, often for months, have become a challenge for physicians all over the world. Unlike most treatments for C. difficile infection (CDI), fecal transplantation is said to be remarkably effective in eradicating disease, but most of the published evidence for its success is anecdotal. Now, Finnish researchers present the largest series to date of CDI patients treated with fecal transplantation.
The investigators reviewed data from 70 adults (mean age, 73; 86% outpatients) who had received up to 12 courses of antibiotics for CDI; most had received 3 to 6 courses. Most stool donors were close relatives of the patient. Transplantations were pe…