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Some evidence suggests that people with Alzheimer disease (AD) have diminished risk for cancer and that cancer survivors have diminished risk for AD. To assess those possibilities, researchers analyzed data from 1278 Framingham Heart Study participants (age ≥65; 61% women) without AD at baseline; 14% were cancer survivors. Mean follow-up was 10 years.
Analyses were adjusted for variables such as age, sex, and smoking status. When the reference group consisted of participants without cancer at baseline, risk for incident probable AD was significantly lower among survivors of any cancer (hazard ratio, 0.67) and survivors of smoking-related cancers (HR, 0.26), and nonsignificantly lower among survivors of non–smoking-related cancers (HR, 0.82).…