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Metal-on-metal total hip replacement is common in the U.S. These implants release metal ions (e.g., chromium, molybdenum, cobalt) into the body, raising concerns that patients with these implants have elevated risk for cancer. In this observational study, U.K. investigators used data from a national joint registry to determine whether metal-on-metal hip replacements are associated with elevated risk for cancer.
Of nearly 300,000 patients who underwent hip replacements during 2003–2010, 41,000 received metal-on-metal implants. Multivariate analysis revealed that, after a mean follow-up of 3 years, metal-on-metal hip replacement was not associated with elevated risks for any cancer diagnosis or death compared with other types of hip replacemen…