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Which, if any, additional cardiac risk markers improve prediction of coronary heart disease (CHD) risk when added to the Framingham Risk Score (FRS)? To answer this question, researchers used data that were collected prospectively from the Rotterdam Study of almost 6000 asymptomatic community-dwelling participants (mean age, 69) without known CHD. At baseline, participants underwent assessment of risk factors to calculate FRS. They also were evaluated for levels of prohormone brain-type natriuretic peptide (NT-proBNP), von Willebrand factor antigen, fibrinogen, C-reactive protein (CRP), homocysteine, and uric acid and for glomerular filtration rate, leukocyte count, coronary artery calcium score (CAC), carotid intima–media thickness, presen…