Adding Newer Cardiac Risk Markers to the Framingham Risk Score

Only 2 of 12 new markers significantly improve risk prediction when added to the FRS.

Which, if any, additional cardiac risk markers improve prediction of coronary heart disease (CHD) risk when added to the Framingham Risk Score (FRS)? To answer this question, researchers used data that were collected prospectively from the Rotterdam Study of almost 6000 asymptomatic community-dwelling participants (mean age, 69) without known CHD. At baseline, participants underwent assessment of risk factors to calculate FRS. They also were evaluated for levels of prohormone brain-type natriuretic peptide (NT-proBNP), von Willebrand factor antigen, fibrinogen, C-reactive protein (CRP), homocysteine, and uric acid and for glomerular filtration rate, leukocyte count, coronary artery calcium score (CAC), carotid intima–media thickness, presen…

Reviewing Author

Jamaluddin Moloo, MD, MPH

Disclosures

Grant / Research supportColorado Health Foundation

Jamaluddin Moloo, MD, MPH

Disclosures

Grant / Research supportColorado Health Foundation

Adding Newer Cardiac Risk Markers to the Framingham Risk Score

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Reviewing Author