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Glucocorticoids can have severe adverse neuropsychiatric effects, but the range and community-based population risk of such effects are unclear. In this U.K. study, researchers used a population-based general practice database to identify 370,000 patients with glucocorticoid exposure and compared them with 1.2 million patients with similar diseases (mostly asthma, lower respiratory tract infection, chronic obstructive pulmonary disease, and polymyalgia rheumatica) who had not taken glucocorticoids.
The overall incidence of any adverse neuropsychiatric effects that occurred within 3 months of a glucocorticoid prescription was 22.2 per 100 person-years of exposure. The incidence of adverse effects, adjusted for age, sex, and history of neurops…