Prediabetes Is Associated with Risk for Stroke

Prediabetes (impaired fasting glucose, impaired glucose tolerance, or both), which affects tens of millions of Americans, is associated with elevated risk for adverse cardiovascular (CV) events. In this meta-analysis of 15 prospective studies involving 760,000 patients, investigators assessed whether prediabetes also is associated with stroke.

In eight studies that defined prediabetes as a fasting glucose level of 100–125 mg/dL, risk for stroke was not elevated after adjustment for multiple CV risk factors. In five studies that defined prediabetes as a fasting glucose level of 110–125 mg/dL, adjusted risk for stroke was significantly elevated (by 21%). In eight studies that defined prediabetes as impaired glucose tolerance or combined impair…