Loading...
Clinical trials have not consistently confirmed that vitamin D supplementation in older adults prevents fractures. To reconcile conflicting data, researchers pooled participant-level data from 11 randomized controlled trials of vitamin D supplementation that involved 31,000 older people (age, ≥65).
In intent-to-treat analyses, vitamin D supplementation lowered risks for hip fracture (hazard ratio, 0.90; P=0.07) and any nonvertebral fracture (HR, 0.93; P=0.03), but these reductions were not significant (for statistical reasons, a P-value of 0.0125 was considered significant). However, the researchers conducted additional analyses that incorporated treatment adherence and supplement use outside the trial: Participants in the highest quartile o…