ACE Inhibitors and ARBs Are Associated with Contrast-Induced Nephropathy

Patients who used angiotensin-converting–enzyme inhibitors or angiotensin-receptor blockers exhibited increased serum creatinine after coronary angiography.

Because angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) affect renal hemodynamics, they could influence risk for developing contrast-induced nephropathy; however, research on this matter has been inconclusive. In a retrospective study from Korea, researchers identified 5300 patients who underwent coronary angiography and pre- and postprocedure serum creatinine measurements. The researchers compared 1322 users of ACE inhibitors or ARBs and 1322 nonusers who were well-matched on other variables by propensity scoring. Contrast-induced nephropathy was defined as a ≥0.3 mg/dL or ≥50% increase in serum creatinine level within 48 hours after angiography.

The incidence of contrast nephropathy was significantly…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose