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In the recent Italian WARFASA trial, aspirin lowered the incidence of recurrent venous thromboembolism (VTE) after first unprovoked VTE events (JW Gen Med May 24 2012). Now, in an international study (ASPIRE), investigators have addressed the same issue in 822 adults who completed 3 to 12 months of standard anticoagulation therapy for unprovoked VTE (42% with pulmonary embolism, 57% with proximal deep venous thrombosis only). Patients then were randomized to receive either 100 mg of aspirin or placebo daily. During average follow-up of 3 years, the following outcomes were noted:
In the intent-to-treat analysis, the annual rate of recurrent VTE (the primary outcome) was 6.5% in the placebo group and 4.8% in the aspirin group (P=0.09).
The annu…