High-Frequency Oscillation Isn't Effective in Acute Respiratory Distress Syndrome

In recent years, use of high-frequency oscillatory ventilation (HFOV) has become more common in adults with acute respiratory distress syndrome (ARDS), but data to support such use are scant. In two studies, researchers evaluated the role of HFOV in ARDS patients.

Investigators in the U.K. randomized 795 patients with moderate-to-severe ARDS to receive either conventional ARDS ventilation or HFOV. HFOV was administered according to a protocol; conventional ventilation was not administered by protocol, but physicians were encouraged to use low tidal volume ventilation. Investigators found no difference in in-hospital mortality or length of stay between the treatment groups. Mean durations of neuromuscular blockade (2.5 vs. 2.0 days) and sedat…