No CV Benefit from Vitamin and Antioxidant Supplements

Although observational studies have linked higher intakes of vitamin- and antioxidant-rich fruits and vegetables with lower cardiovascular (CV) risk, randomized trials of vitamin and antioxidant supplements have yielded conflicting results. Most prior meta-analyses of these trials have involved individual vitamin or antioxidant supplements, and no meta-analysis has included comprehensive randomized trial data on this topic. In this meta-analysis, investigators reviewed data from 50 randomized, controlled trials that involved 295,000 participants to assess the efficacy of vitamin and antioxidant supplements in preventing major adverse CV events.

In the overall analysis, supplemental vitamins and antioxidants had no effect on risk for CV-relat…