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The original article on which this summary is based has been retracted after irregularities in the randomization process were identified. After a reanalysis of the data to adjust for these irregularities, the article has been republished, and the results are essentially unchanged.
The so-called Mediterranean diet is thought, mostly on the basis of observational studies, to confer cardiovascular benefit. Now, Spanish researchers have put this diet to the ultimate test — a large, randomized, primary-prevention trial.
About 7500 people (age range, 55–80) without known cardiovascular disease but with either diabetes or ≥3 nondiabetes cardiac risk factors were randomized to one of three diets:
Mediterranean diet supplemented with extra-virgin olive…