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Morton neuroma is a painful fibrotic thickening of an interdigital nerve in the foot, usually between the third and fourth distal metatarsals. In this patient-blinded trial from Scotland, researchers randomized 131 patients (mean age, 53; 85% women) with Morton neuroma to receive injections — under ultrasound guidance — of methylprednisolone plus lidocaine or lidocaine alone.
On a global 100-point scale of foot health, methylprednisolone recipients had significantly higher scores at 1 month and 3 months than controls had. Mean scores (≈45 at baseline) changed minimally in the control group and increased by 14 points more in the steroid group than in the control group. On most secondary endpoints (by which pain, function, and health were asse…