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In recent years, considerable improvements have been made in therapy and treatment outcomes among patients with non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL), and researchers in many ongoing clinical trials are testing additional novel agents and regimens. The International Working Group (IWG) response criteria that were first proposed in 1999 (J Clin Oncol 1999; 17:1244) have been a valued reference for standardizing response assessments and enhancing comparison of results across various studies.
The International Harmonization Project, with research participants from North America and Europe, has updated the IWG criteria by incorporating the results of positron emission tomography (PET) scanning and bone-marrow immunologic marker stu…