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Epidemiologic studies suggesting that a folate-deficient diet can increase risk for colorectal cancer have raised interest in folic acid supplementation. The effect of dietary folic acid supplements on risk for developing colorectal polyps or cancer, and the potential harm from such supplements, can be assessed only in a controlled clinical study.
Researchers now report results from a randomized placebo-controlled trial, the Aspirin/Folate Polyp Prevention Study. The study had a 3×2 factorial design, in which 1021 participants with histories of colorectal adenoma were assigned to daily aspirin (81 mg or 325 mg) or placebo and to daily folic acid (1 mg) or placebo. The participants were predominantly male (64%) and white (85%). The primary en…