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The molecular genetics of prostate cancer have been more vexing to elucidate than those of other epithelial neoplasms, such as breast and colon cancers. However, mutations in the tumor-suppressor gene BRCA2 clearly are associated with higher risk for developing prostate cancer. Although several small studies have suggested a correlation between BRCA2 mutations and aggressive natural history for prostate cancer, confirmatory evidence is lacking, and little information is available to predict how specific genotypes will affect disease course.
In this population-based study, investigators used data from the Icelandic Cancer Registry, which contains data on all cancers that have been diagnosed in Iceland since 1955, plus additional data, from 19…