Effect of EBV in Diffuse Large B-Cell Lymphoma

For Asian patients, overall survival and progression-free survival generally were shorter with EBV-positive DLBCL than with EBV-negative DLBCL.

The Epstein-Barr virus (EBV) has a pathogenic role in several lymphomas, including Burkitt lymphoma, extranodal NK–T-cell lymphoma nasal type, and Hodgkin lymphoma; however, the pathogenicity and prognostic role of EBV in diffuse large B-cell lymphoma (DLBCL) have not been established. In several case reports and small series, primarily from Asia, researchers have identified the presence of EBV in a subset of DLBCL patients. To further define the frequency and prognostic effect of EBV in DLBCL, investigators in Korea analyzed a retrospective cohort of 380 patients with de novo DLBCL who had pathologic specimens and clinical data available. DLBCL had been diagnosed in these patients from 1994 through 2005; 73% were treated with CHOP (cycloph…

Reviewing Author

Michael E. Williams, MD

Disclosures

Consultant/Advisory BoardAbbVie; AstraZeneca; Beigene; Janssen; Pharmacyclics

Grant/Research SupportJanssen

Editorial BoardsAmerican Board of Internal Medicine (ABIM) Hematology Longitudinal Knowledge Approval Committee

Michael E. Williams, MD

Disclosures

Consultant/Advisory BoardAbbVie; AstraZeneca; Beigene; Janssen; Pharmacyclics

Grant/Research SupportJanssen

Editorial BoardsAmerican Board of Internal Medicine (ABIM) Hematology Longitudinal Knowledge Approval Committee