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Reirradiation has been investigated as a treatment option for head and neck cancer patients whose disease has recurred within a radiation port and for whom surgical salvage is not an option. Available studies demonstrated that reirradiation is feasible and capable of rendering a small but significant percentage of patients disease free.
To investigate the role of postoperative reirradiation for recurrent head and neck cancers with high risk for local recurrence, researchers conducted a phase III, randomized trial involving patients from French and Belgian centers who underwent surgery for recurrent or second primary tumors in previously irradiated areas. Eligibility criteria included head and neck squamous cell carcinoma in a field irradiate…