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Chemoprevention of major epithelial cancers — a major focus of clinical research during the past 10 to 15 years — has achieved some measure of success, notably regarding the activity of tamoxifen in breast cancer (JW Oncol Hematol Mar 12 2007 and J Natl Cancer Inst 1998; 90:1371). Such advances in prostate cancer have been less forthcoming, although researchers have reported hypothesis-generating data regarding the potential for selenium (S) and vitamin E (E) to lower prostate cancer incidence and overall disease-related mortality (J Natl Cancer Inst 1998; 90:1219). These data, along with epidemiologic and preclinical data, led an international group of investigators to conduct the phase III placebo-controlled Selenium and Vitamin E Cancer …