Survival After Resection of Hepatocellular Carcinoma

Tumor size >2 cm, tumor multifocality, and microvascular invasion predicted poor prognoses among patients with early disease.

The incidence of hepatocellular carcinoma (HCC) is rising in the U.S., and overall survival at 3 years is only 5%. When diagnosed early, HCC is potentially amenable to surgical resection. But predicting prognosis after resection is difficult because existing studies and staging systems tend to categorize patients with early HCC as one group.

To identify predictors of survival after resection in patients with early HCC, researchers assessed cancer registry data for 788 patients with tumors <5 cm and without lymph node involvement, metastases, or major vascular invasion. After surgery, overall median survival was 45 months, and 5-year survival was 39%. Tumor size >2 cm, tumor multifocality, and presence of microvascular invasion predicted adve…

Reviewing Author

Henry Mark Kuerer, MD, PhD, FACS

Disclosures

Speaker's BureauPhysicians’ Education Resource, LLC

RoyaltiesMcGraw-Hill Professional; UpToDate, Inc.

Editorial BoardsAnnals of Surgical Oncology

Leadership Positions in Professional SocietiesAmerican Society of Breast Surgeons (Chair, Publications Committee)

Henry Mark Kuerer, MD, PhD, FACS

Disclosures

Speaker's BureauPhysicians’ Education Resource, LLC

RoyaltiesMcGraw-Hill Professional; UpToDate, Inc.

Editorial BoardsAnnals of Surgical Oncology

Leadership Positions in Professional SocietiesAmerican Society of Breast Surgeons (Chair, Publications Committee)