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Genome-wide association studies have identified low-penetrant single nucleotide polymorphisms (SNPs) that raise breast cancer risk slightly; moreover, certain SNPs might predispose women to develop specific breast cancer subtypes (e.g., estrogen receptor [ER]-positive breast cancer, lobular breast cancer, bilateral breast cancer). To clarify the relations between SNPs (individually and in combination) and breast cancer risk, investigators conducted genotyping for 14 previously identified SNPs in 10,306 women with breast cancer and 10,393 women without the disease.
Seven SNPs were confirmed to be associated with excess risk for breast cancer; of these, three were associated significantly with different breast cancer subtypes. Because the seve…