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Penile cancer, an uncommon neoplasm, often appears as locally advanced disease and is managed primarily with surgery. Despite improvements in surgical management, systemic failure rates are high, and chemotherapy has historically yielded little benefit.
To test an integrated approach of neoadjuvant chemotherapy followed by surgery for locally advanced disease, investigators at a cancer center in Texas conducted a phase II trial involving 30 men with histologically confirmed squamous cell carcinoma of the penis (stage TX, N2–3, M0) who were enrolled during 8 years. Patients with enlarged pelvic lymph nodes on computed tomography were eligible without biopsy confirmation. Neoadjuvant chemotherapy comprised 4 cycles (every 3 to 4 weeks) of pacl…