PSA Velocity: A Criterion for Prostate Biopsy?

Adding prostate-specific antigen velocity as a trigger for biopsy did not improve predictive accuracy beyond that of using PSA values alone.

Patient selection for prostate biopsy is typically based on several factors including age, race, prostate-specific antigen (PSA) values (both free and total), and clinical exam. Another criterion for prostate biopsy, as cited in guidelines by the National Comprehensive Cancer Network and the American Urological Association, is high PSA velocity (rate of change of PSA over time), even for men with low absolute PSA values and negative digital rectal exams.

To assess the utility of using PSA velocity values as a basis for recommending prostate cancer biopsies, investigators evaluated 5652 healthy men (≥55 with normal digital rectal exam, baseline PSA ≤3.0 ng/mL, and no history of prostate cancer) who participated in the control arm of the Prost…

Reviewing Author

Robert Dreicer, MD, MS, FACP

Disclosures

Consultant/Advisory BoardAstellas; Aveo; Bayer; Gilead; Merck; Pfizer; Propella; Macrogenics

Editorial BoardsCurrent Urology Reports

Robert Dreicer, MD, MS, FACP

Disclosures

Consultant/Advisory BoardAstellas; Aveo; Bayer; Gilead; Merck; Pfizer; Propella; Macrogenics

Editorial BoardsCurrent Urology Reports

PSA Velocity: A Criterion for Prostate Biopsy?

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Reviewing Author