Breast-conserving treatments for DCIS are associated with excellent prognoses.
Incidence of ductal carcinoma in situ (DCIS) has risen substantially during the last 2 decades as a result of screening mammography. However, mammographically detected DCIS is often clinically silent and substantially less extensive than the large DCIS lesions that once were common at diagnosis. In addition, therapeutic approaches to DCIS have evolved: For most patients, breast conservation (i.e., lumpectomy and radiation therapy with or without tamoxifen as appropriate) is feasible.
The National Surgical Adjuvant Breast and Bowel Project (NSABP) B-17 and B-24 trials were designed to assess outcomes of breast-conserving treatments for DCIS. In the B-17 trial, 818 patients with localized DCIS were randomized to lumpectomy only (LO) or lumpect…
Reviewing Author
DisclosuresConsultant/Advisory BoardLilly; AstraZeneca; Gilead
Grant/Research SupportBreast Cancer Research Foundation
Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment
Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)
DisclosuresConsultant/Advisory BoardLilly; AstraZeneca; Gilead
Grant/Research SupportBreast Cancer Research Foundation
Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment
Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)