Breast-Conserving Therapy vs. Mastectomy for Triple-Negative Breast Cancer

In women with T1-2N0 TNBC, risk for local regional recurrence was lower after lumpectomy plus radiotherapy than after modified radical mastectomy.

Triple-negative breast cancer (TNBC; negative for estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2) is associated with unfavorable prognosis, in part because of poor response to systemic therapies and radiotherapy as well as high rates of local regional recurrence (LRR; J Clin Oncol 2006; 24:5652 and J Clin Oncol 2008; 26:1419). In a retrospective cohort study involving 768 patients with TNBC in Alberta, Canada, researchers evaluated LRR-free survival following breast-conserving therapy (BCT; lumpectomy and adjuvant radiation therapy [RT]) or modified radical mastectomy (MRM) with or without RT; in a subgroup of 468 patients with T1-2N0 TNBC, outcomes following BCT or MRM were compared.

At median follo…

Reviewing Author

Henry Mark Kuerer, MD, PhD, FACS

Disclosures

Speaker's BureauPhysicians’ Education Resource, LLC

RoyaltiesMcGraw-Hill Professional; UpToDate, Inc.

Editorial BoardsAnnals of Surgical Oncology

Leadership Positions in Professional SocietiesAmerican Society of Breast Surgeons (Chair, Publications Committee)