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Cytogenetic analysis with standard karyotype and FISH (fluorescent in-situ hybridization) provides important prognostic information for patients with newly diagnosed acute myeloid leukemia (AML). A number of specific gene mutations that correlate with prognosis and treatment response have also been identified.
Now, investigators have used a panel of 18 genes previously shown to correlate with patient outcomes to analyze diagnostic peripheral blood and bone marrow samples from 398 AML patients (age, <60) who had been enrolled in a randomized trial of induction therapy with standard versus dose-intensive daunorubicin (JW Oncol Hematol Oct 20 2009). The researchers validated the results using samples from another 104 AML patients.
Mutation of ≥1…