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The factor V Leiden (FVL) mutation is associated with a greater risk for deep vein thrombosis (DVT) than for pulmonary embolism (PE); this observation is paradoxical because most pulmonary emboli are thought to arise from DVT. However, factors other than FVL might increase the risk for one type of thrombosis versus another.
To explore this possibility, investigators from the Leiden University Medical Center in the Netherlands performed a systematic review of published studies of risk factors for DVT and PE and calculated risk estimates from a large population-based, case-control study. The table shows the risks for DVT and PE associated with several patient factors that are implicated in venous thrombosis, including body mass index, leg inju…
