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Obesity is associated with a two- to threefold increased risk for venous thrombosis (VT), but how obesity influences this risk is unclear. In particular, the hemostatic factors that contribute to thrombosis have not been previously identified.
To examine the relationship between obesity, hemostasis, and risk for VT, investigators from the Netherlands and Norway studied two large cohorts of VT patients and healthy controls. Body-mass index (BMI), factor VIII (FVIII), activated protein C resistance (aPCR), factor V Leiden (FVL), and blood group were examined in a Dutch cohort of 474 patients and 474 controls, and BMI, FVL, and blood group were examined in a Norwegian cohort of 515 patients and 1476 controls.
In the Dutch cohort, BMI was directl…