SRSF2 Mutations and Survival in Primary Myelofibrosis

The variable prognosis in patients with primary myelofibrosis (PM) has prompted investigators to search for survival factors in this disorder. Interest has recently focused on components of the spliceosome, particularly on mutations in the genes responsible for RNA splicing.

Now, researchers report that one such gene, SRSF2, was mutated in 32 of 187 PM patients (17%). Patients with this mutation were older (>65 vs. ≤65; P<0.01), trended toward requiring more transfusions (47% vs. 30%; P=0.06), had higher risk scores on the Dynamic Prognostic Scoring System (DIPSS; P=0.03), and were more likely to have mutations in the IDH1 and IDH2 genes (P<0.01). Findings with regard to survival were as follows:

• SRSF2 mutations were associated with shortened…