In women aged 25 to 39, the incidence of stage IV disease has increased, on average, 2.07% per year from 1976 to 2009; no similar trend was observed in older women.
A new report analyzing the U.S. National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database suggests that the incidence of de novo metastatic (stage IV) breast cancer in young women is increasing. To identify this trend, investigators obtained data on breast cancer incidence, incidence trends, and survival rates as a function of age and extent of disease at diagnosis from three SEER registries spanning the years 1973 to 2009, 1992 to 2009, and 2000 to 2009.
The incidence of stage IV breast cancer at diagnosis for young women (aged 25 to 39) increased from 1.53 per 100,000 (95% confidence interval, 1.01–2.21) in 1976 to 2.90 per 100,000 (95% CI, 2.31–3.59) in 2009. This difference represents an absolute increase of 1…
Reviewing Author
DisclosuresConsultant/Advisory BoardLilly; AstraZeneca; Gilead
Grant/Research SupportBreast Cancer Research Foundation
Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment
Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)
DisclosuresConsultant/Advisory BoardLilly; AstraZeneca; Gilead
Grant/Research SupportBreast Cancer Research Foundation
Editorial BoardsClinical Breast Cancer; Oncology; Annals of Surgery; Breast Cancer Research and Treatment
Leadership Positions in Professional SocietiesNational Comprehensive Cancer Network (Chair, Breast Cancer Panel); American Board of Internal Medicine (Medical Oncology Board)