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Genetic conditions associated with venous and arterial thrombosis include relatively rare disorders such as dyslipidemia and hyperhomocystinemia. However, recent reports suggest that ABO blood group (non-O) is also an important risk factor.
To examine associations among ABO blood groups, inherited thrombophilias (factor V Leiden [FVL] and prothrombin G20210A), and venous and arterial thrombotic events, investigators analyzed data from 60,000 persons in the Danish general population who were enrolled in two independent studies.
Venous thromboembolism (VTE) was identified in 3.5% of the study cohort, and was significantly associated with non-O blood group, FVL R506Q mutation, and prothrombin G20210A mutation (see table). Combining non-O blood t…
