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Many treatment options are available for migraines in adults, but only ibuprofen, acetaminophen, and sumatriptan nasal spray are supported by consensus statements as being effective in children and adolescents. In an industry-supported, multicenter study designed to address the high rate of placebo responses in adolescents, 171 adolescents (age range, 12–17) with migraines were first given a placebo challenge, and then those who had no response within 15 minutes were randomized to receive either placebo or zolmitriptan (5 mg) nasal spray.
Response was defined as a 2-point reduction in headache intensity on a 4-point scale. During a total of 275 migraine attacks, zolmitriptan was associated with a significantly higher response rate than place…