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Achondroplasia is the most common dwarfing condition, and many natural history and quality-of-life studies have been undertaken because of the relatively large number of affected individuals. However, few studies have assessed risk for death in adults. To compare mortality patterns between individuals with achondroplasia and the general population, researchers in Texas followed 793 people with achondroplasia for 42 years and analyzed their vital statistics using three mortality databases.
Sudden death related to small foramen magnum is a well-known early complication associated with achondroplasia. However, I was surprised to learn that cardiovascular disease–related mortality also was associated with achondroplasia, with risk 10 times highe…