The Effect of Secondhand Smoke in Children with Cystic Fibrosis

Exposure to secondhand smoke amplifies pulmonary toxicity in some genotypes of cystic fibrosis.

To explore the interaction between secondhand smoke and pulmonary toxicity in children with different cystic fibrosis (CF) genotypes, researchers compared outcomes between 188 children who were exposed to the environmental toxin in the home after birth and 624 who were not exposed at home and between 129 children who were exposed during gestation and 651 children who were not exposed during gestation.

Cross-sectional and longitudinal measures of forced expiratory volume in the first second of expiration (FEV₁) were worse in children with CF who were exposed to secondhand smoke in the home than in those who were not, particularly in nonwhites. Maximum FEV₁ was similar in home-exposed and unexposed children with ΔF508 homozygosity; however, no…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)