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Common variable immunodeficiency (CVID) refers to a constellation of acquired B-cell disorders that have similar presentations and laboratory findings. Patients with CVID have recurrent infections with encapsulated organisms as well as chronic gastrointestinal, skin, and soft-tissue infections. Some patients have combined B- and T-cell dysfunction that can lead to autoimmune problems and an increased risk for malignancy. The estimated prevalence of CVID is 1 case per 30,000 whites, but the disease might be underdiagnosed. In this study, researchers examined clinical characteristics of 252 adult patients with CVID (56% female; 90% white) who were enrolled from 2004 through 2007 in a French national study of adults with primary hypogammaglobu…