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Influenza vaccination now is recommended for infants at age 6 months. In a randomized clinical trial, investigators in Bangladesh examined whether vaccinating women in their third trimesters of pregnancy would prevent influenza in newborns. The 344 pregnant women received either the inactivated influenza vaccine or 23-valent pneumococcal polysaccharide vaccine (control) and were interviewed weekly for 6 months after delivery.
Compared with infants whose mothers received pneumococcal vaccine, infants whose mothers received influenza vaccine were significantly less likely to have laboratory-confirmed influenza (6 vs. 16 infants; estimated effectiveness, 63%). Infants in the influenza-vaccine group also were significantly less likely to have re…