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Controversy exists about the optimal duration of antibiotic therapy for treatment of septic arthritis in children and about the role of surgical intervention, particularly with hip and shoulder involvement. In a multicenter, manufacturer-sponsored, open-label trial, sponsored by the maker of a C-reactive protein (CRP) test, investigators randomized 130 children (mean age, 6 years) who presented to seven hospitals in Finland from 1983 to 2005 with culture-proven septic arthritis to receive 10 or 30 days of antimicrobial therapy (clindamycin or a first-generation cephalosporin administered intravenously for 2 to 4 days and then orally). Children with concomitant osteomyelitis were excluded.
In both groups, treatment duration was extended for c…